lab techs looking at EEG tracings on computer

Research Projects

The current CSCN projects are:

Project 1

Risk factors for cardiovascular and cognitive dysfunctions in adult obstructive sleep apnea (OSA) patients: Identification of biomarkers and impact of working schedules

Project information 

Objectives:

  1. To determine whether inflammatory and genetic markers predict the occurrence of cardiovascular disease (myocardial infarction, emergency angioplasty, cardiac death), metabolic disease (renal failure) and cognitive dysfunctions in OSA patients after controlling for a variety of potential confounders (including disease severity).
  2. To evaluate how work schedules interact with inflammatory biomarkers in OSA patients.

Protocol: https://www.cscnweb.ca/admin/cms/images/large/cscn_project_1_protocol.pdf

 

Project 1 committee

Chair: Najib Ayas (University of British Columbia)
Co-chairs: Patrick Hanly (University of Calgary) and Robert Skomro (University of Saskatchewan)

Other members:

  • John Fleetham (University of British Columbia)
  • Tami Martino (University of Guelph)
  • Clodagh Ryan (University of Toronto)
  • Frédéric Sériès (Université Laval)
  • Eric Smith (University of Calgary)
  • Simon Warby (Université de Montréal)
  • One patient representative

Project 2

Identification of obese children most at risk of obstructive sleep apnea (OSA) and the evaluation of neurocognitive, metabolic and cardiovascular functions

Project information 

Objective:

To identify obese children most at risk of OSA and to determine the independent effects of OSA on cardiovascular, metabolic, and cognitive functions (prior to and after treatment for OSA).

Protocol: https://www.cscnweb.ca/admin/cms/images/large/cscn_project_2_protocol.pdf

 

Project 2 committee:

Chair: Indra Narang (University of Toronto)
Co-chair: Sherri Katz (University of Ottawa)

Other members:

  • Adetayo Adeleye (University of Calgary)
  • Suhail Al-Saleh (University of Toronto)
  • Jean-Philippe Chaput (University of Ottawa)
  • Evelyn Constantin (McGill University)
  • Reut Gruber (McGill University)
  • Joanna MacLean (University of Alberta)
  • Clodagh Ryan (University of Toronto)
  • Manisha Witmans (University of Alberta)
  • One patient representative

Project 3

To evaluate how obstructive sleep apnea (OSA) impacts the cerebral mechanisms underlying Mild Cognitive Impairment (MCI)

Project information 

Objectives:

To evaluate how OSA impacts cognitive and cerebral biomarkers (beta-amyloid deposition, tau level in the cerebrospinal fluid, atrophy in the entorhinal cortex and the hippocampus, vascular brain damages) in patients with MCI.

Protocol: https://www.cscnweb.ca/admin/cms/images/large/cscn_project_3_protocol.pdf

 

Project 3 committee:

Chair: Nadia Gosselin (Université de Montréal)
Co-chair: Dominique Lorrain (Université de Sherbrooke)

Other members:

  • Marcel Alexander Baltzan (McGill University)
  • Julie Carrier (Université de Montréal)
  • Thanh Dang-Vu (Concordia University)
  • Jean-François Gagnon (Université du Québec à Montréal)
  • Jacques Montplaisir (Université de Montréal)
  • Dominique Petit (Université de Montréal)
  • Ronald Postuma (McGill University)
  • One patient representative

Project 4

To improve access and adherence to obstructive sleep apnea (OSA) treatment

Project information 

Aim 1

Improving Access to Care: Evaluation of a “Fast Track” Respiratory Therapy Clinic for Patients with Suspected Severe OSA

Objectives:

  1. To compare the clinical effectiveness of a clinic led by alternative care providers for patients with suspected severe OSA to physician-led management
  2. To compare the cost-effectiveness of these models of care using data on healthcare utilization, costs, and patients quality of life.

Protocol: https://www.cscnweb.ca/admin/cms/images/large/cscn_projet_4_aim_1_protocol.pdf

Publication: for pdf, click here.

 

Aim 2

Economic Consequences of Improving Adherence to care: The Effect of Patient Decision Aids on Adherence

Objective

To determine whether treatment preference is associated with adherence to therapy.

Protocol: https://www.cscnweb.ca/admin/cms/images/large/cscn_projet_4_aim_2_protocol.pdf

 

Project 4 committee

Chair: Sachin Pendharkar (University of Calgary)

Other members:

  • Fernanda Almeida (University of British Columbia)
  • Najib Ayas (University of British Columbia)
  • Nick Bansback (University of British Columbia)
  • Mark Fenton (University of Saskatchewan)
  • Nelly Huynh (Université de Montréal)
  • Marcus Povitz (Western University)
  • One patient representative