Papers published
Project 1
- Beaudin AE, Raneri JK, Ayas NT, Skomro RP, Smith EE, Hanly PJ. Contribution of hypercapnia to cognitive impairment in severe sleep-disordered breathing. J Clin Sleep Med. 2021 Jul 27. doi: 10.5664/jcsm.9558. Epub ahead of print. PMID: 34286691.
- Beaudin AE, Raneri JK, Ayas NT, Skomro RP, Fox N, Hirsch Allen AM, Bowen MW, Nocon A, Lynch EJ, Wang M, Smith EE, Hanly PJ; Canadian Sleep and Circadian Network (CSCN). Cognitive Function in a Sleep Clinic Cohort of Patients with Obstructive Sleep Apnea. Ann Am Thorac Soc. 2020 Nov 4. doi: 10.1513/AnnalsATS.202004-313OC. Epub ahead of print. PMID: 33147067.
- Allen AH, Beaudin AE, Fox N, Raneri JK, Skomro RP, Hanly PJ, Mazzotti DR, Keenan BT, Smith EE, Goodfellow SD, Ayas NT. Symptom subtypes and cognitive function in a clinic-based OSA cohort: a multi-centre Canadian study. Sleep Med. 2020 Oct;74:92-98. doi: 10.1016/j.sleep.2020.05.001. Epub 2020 May 11. PMID: 32841852.
- Peres BU, Hirsch Allen AJ, Fox N, Laher I, Hanly P, Skomro R, Almeida F, Ayas NT; Canadian Sleep and Circadian Network. Circulating biomarkers to identify cardiometabolic complications in patients with Obstructive Sleep Apnea: A systematic review. Sleep Med Rev. 2019 Apr;44:48-57.
- Franczak A, Bil-Lula I, Sawicki G, Fenton M, Ayas N, Skomro R. Matrix metalloproteinases as possible biomarkers of obstructive sleep apnea severity - A systematic review. Sleep Med Rev. 2019 Aug;46:9-16.
- Ayas NT, Hirsch Allen AJ, Fox N, Peres B, Mehrtash M, Humphries KH, Jen R, Taylor CM, van Eeden SF. C-Reactive Protein Levels and the Risk of Incident Cardiovascular and Cerebrovascular Events in Patients with Obstructive Sleep Apnea. Lung. 2019 Aug;197(4):459-464.
Project 2
- Sunkonkit K, Selvadurai S, Voutsas G, Benzon D, Baker A, Trinh M, Narang I. The impact of the COVID-19 pandemic on positive airway pressure usage in children with sleep-disordered breathing. Sleep Breath. 2021 Jun 9:1-8. doi: 10.1007/s11325-021-02409-w. Online ahead of print. PMID: 34105105
- Katz SL, Blinder H, Naik T, Barrowman N, Narang I; Canadian Sleep and Circadian Network. Does neck circumference predict obstructive sleep apnea in children with obesity? Sleep Med. 2021 Feb;78:88-93.
- Selvadurai S, Voutsas G, Kassner A, Massicotte C, Katz SL, Propst EJ, Narang I. Positional Obstructive Sleep Apnea in an Obese Pediatric Population. J Clin Sleep Med. 2020 April 14. doi: 10.5664/jcsm.8496.
Project 3
- Legault J, Thompson C, Martineau-Dussault MÈ, André C, Baril AA, Martinez Villar G, Carrier J, Gosselin N. Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors. Brain Sci. 2021 May 27;11(6):706. doi: 10.3390/brainsci11060706. PMID: 34071739; PMCID: PMC8226698.
- Zolfaghari S, Yao C, Thompson C, Gosselin N, Desautels A, Dang-Vu TT, Postuma RB, Carrier J. (2020) Effects of menopause on sleep quality and sleep disorders: Canadian Longitudinal Study on Aging. Menopause Journal. 27.3.
- Cross NE, Carrier J, Postuma RB, Gosselin N, Kakinami L, Thompson C, Chouchou F, Dang-Vu TT. Association between insomnia disorder and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging. Sleep. 2019 Aug 1;42(8).
- Gosselin N, Baril AA, Osorio RS, Kaminska M, Carrier J. Obstructive Sleep Apnea and the Risk of Cognitive Decline in Older Adults. Am J Respir Crit Care Med. 2019 Jan 15;199(2):142-148.
- Baril AA, Carrier J, Lafrenière A, Warby S, Poirier J, Osorio RS, Ayas N, Dubé MP, Petit D, Gosselin N; Canadian Sleep and Circadian Network. Biomarkers of dementia in obstructive sleep apnea. Sleep Med Rev. 2018 Dec;42:139-148.
- Yao C, Fereshtehnejad SM, Keezer MR, Wolfson C, Pelletier A, Postuma RB. Risk factors for possible REM sleep behavior disorder: A CLSA population-based cohort study. Neurology. 2018 Dec 26 (epub).
Project 4
- Pendharkar SR, Blades K, Kelly JE, Tsai WH, Lien DC, Clement F, Woiceshyn J, McBrien KA. Perspectives on primary care management of obstructive sleep apnea: a qualitative study of patients and health care providers. J Clin Sleep Med. 2021 Jan 1;17(1):89-98
- Billings ME, Pendharkar SR. Alternative Care Pathways for Obstructive Sleep Apnea and the Impact on Positive Airway Pressure Adherence: Unraveling the Puzzle of Adherence. Sleep Med Clin. 2021 Mar;16(1):61-74.
- Braganza MV, Hanly PJ, Fraser KL, Tsai WH, Pendharkar SR. Predicting CPAP failure in patients with suspected sleep hypoventilation identified on ambulatory testing. J Clin Sleep Med. 2020 Sep 15;16(9):1555-1565.
- Corrigan J, Ogah I, Ip-Buting A, Sharpe H, Laratta CR, Peller P, Tsai WH, Pendharkar SR. An evaluation of rural-urban disparities in treatment outcomes for obstructive sleep apnoea: study protocol for a prospective cohort study. ERJ Open Res. 2020 Oct 5;6(4):00141-2020.
- Thornton CS, Tsai WH, Santana MJ, Penz ED, Flemons WW, Fraser KL, Hanly PJ, Pendharkar SR. Effects of Wait Times on Treatment Adherence and Clinical Outcomes in Patients With Severe Sleep-Disordered Breathing: A Secondary Analysis of a Noninferiority Randomized Clinical Trial. JAMA Netw Open. 2020 Apr 1;3(4):e203088. doi: 10.1001/jamanetworkopen.2020.3088.
- Pendharkar SR, Tsai WH, Penz ED, Santana MJ, Ip-Buting A, Kelly JE, Flemons WW, Fraser KL, Hanly PJ. A randomized controlled trial of an alternative care provider clinic for severe sleep disordered breathing. Ann Am Thor Soc 2019; Dec;16(12):1558-1566.
- Pendharkar SR, Povitz M, Bansback N, George CFP, Morrison D, Ayas NT. Testing and treatment for obstructive sleep apnea across Canada: funding models need to change. CMAJ 2017;189:E1524-1528.
- Ip-Buting A, Kelly JE, Santana MJ, Penz ED, Flemons WW, Tsai WH, Fraser KL, Hanly PJ, Pendharkar SR. Evaluation of an alternative care provider clinic for severe sleep disordered breathing: a study protocol for a randomized controlled trial. BMJ Open 2017;7:e014012.
- Laratta CR, Ayas NT, Povitz M, Pendharkar SR. Diagnosis and treatment of obstructive sleep apnea in adults. CMAJ. 2017 Dec 4;189(48):E1481-E1488. doi: 10.1503/cmaj.170296. PMID: 29203617; PMCID: PMC5714700.
Presentations
Project 1
- Franczak A, Bil-Lula I, Sawicki G, Fenton M, Skomro R: Urinary MMP-2 as a potential biomarker of severity of obstructive sleep apnea. Clinica Chimica Acta, 493:S9, June 2019, doi: 10.1016/j.cca.2019.04.024. 23rd European Congress of Clinical Chemistry and Laboratory Medicine, Barcelona, Spain, May 2019.
- Franczak A, Sawicka J, Nocon A, Bil-Lula I, Fenton M, Hanly P, Beaudin A, Sawicki G, Skomro R: Urinary matrix metalloproteinase-2 (MMP-2) activity in patients with obstructive sleep apnea. World Sleep Congress 2019, Vancouver, Canada, September 2019.
- Beaudin A, Ayas NT, Skomro RP, Raneri JK, Lynch EJ, Smith EE, Hanly PJ. Impact of hypoventilation on cognitive function in patients with severe obstructive sleep apnea. World Sleep Congress 2019, Vancouver, Canada, September 2019.
- Beaudin A, Skomro RP, Ayas NT, Raneri JK, Nocon A, Fox N, Ahmed SB, Hanly PJ. Prevalence of patients at risk for progression of chronic kidney disease in a sleep clinic cohort of with obstructive sleep apnea. World Sleep Congress 2019, Vancouver, Canada, September 2019.
- Ayas NT. Can biomarkers be used to predict adverse outcomes in patients with OSA? World Sleep Congress 2019, Vancouver, Canada, September 2019.
- Ayas NT. Adjunctive Pharmacology in Sleep Apnea to Reduce CVD Risk in Symposium: Sleep Apnea and Cardiovascular Disease: Phenotypes, Pharmacology, and Risk Stratification. Chest 2019.
- Hanly P. Sleep apnea and kidney disease: A bidirectional relationship. World Sleep Congress 2019, Vancouver, Canada, September 2019.
- Ayas NT. Cerebrovascular Disease and Stroke. World Sleep Congress 2019, Vancouver, Canada, September 2019. (CME course)
- Hanly P. Kidney Disease (Mechanisms and Intervention studies). World Sleep Congress 2019, Vancouver, Canada, September 2019. (CME course)
- Ayas NT. The CSCN Database. SAGIC meeting, Iceland 2018.
- Ayas N. Symposium: World Sleep meeting 2017, Prague. Impact of intermittent hypoxia on kidney histology: Evidence from animal models.
- Hanly P. Symposium: World Sleep meeting 2017, Prague. Effect of sleep apnea on kidney function: Evidence from human studies.
Project 2
- Handa S, Voutsas G, Katz S, Kassner A, Blinder H, Naik T, Narang I. The Impact of a Short Apnea-Hypopnea Event Duration on Anthropometric Measures in an Obese Pediatric Population, Poster presented at the World Sleep Society Meeting, September 20-25, 2019, Vancouver.
- Voutsas G, Selvadurai S, Kassner A, Katz S, Narang I. Prevalence and Factors Associated with Positional Obstructive Sleep Apnea in an Obese Pediatric Population, Poster presented at the World Sleep Society Meeting, September 20-25, 2019, Vancouver.
- Mustonen T, Voutsas G, Katz S, Kassner A, naik T, Blinder H, Thakur R, Narang I. Neurocognitive Functioning in an Obese Pediatric Population with and without Obstructive Sleep Apnea, Poster presented at the World Sleep Society Meeting, September 20-25, 2019, Vancouver.
- Katz S, Blinder H, Naik T, Barrowman N, Harrison MA, Narang I. Does Neck Circumference Predict Obstructive Sleep apnea in Children with Obesity? Poster presented at the World Sleep Society Meeting, September 20-25, 2019, Vancouver.
- Voutsas G, Selvadurai S, Kassner A, Katz S, Narang I. Prevalence and Factors Associated with Positional Obstructive Sleep Apnea in an Obese Pediatric Population, Poster presented at the 2019 Annual Research Day in Respirology, June 19, 2019, Toronto.
Project 3
- Legault J, Thompson C, Martineau-Dussault ME, Carrier J, Dang-Vu TT, Lorrain D, Gosselin N, and the CIMA-Q group. (2020). Obstructive Sleep Apnea in Older Adults: Differential Cognitive Impairment Moderated by Sex? Alzheimer's Association International Conference 2020 (congrès virtuel).
- Legault J, Thompson C, Martineau-Dussault ME, Carrier J, Gosselin N, and the CIMA-Q group. Association between risk of obstructive sleep apnea and cognitive decline in older adults.
- 16e Journe?es de la recherche du re?seau que?be?cois de recherche sur le vieillissement, Montre?al, 2019.
- Journe?e de la recherche du Centre inte?gre? universitaire de sante? et de services sociaux du Nord-de-l’I?le-de-Montre?al 2019;
- 7e Journe?e scientifique de NeuroQAM, Montre?al, 2019.
- Gosselin N. (2019) Obstructive sleep apnea and risk of cognitive decline, Sleep Grand Rounds, University of Toronto, April 2019. [Oral presentation]
- Sheida Zolfaghari, Kaberi Dasgupta, Ronald B. Postuma. “Restless Leg Syndrome and Cardiovascular and Cerebrovascular Diseases in The Canadian Longitudinal Study on Aging”, World Sleep Congress, 20-25 September 2019, Vancouver, Canada [Oral presentation]
- Yao C, Wolfson C, Pelletier A, Postuma RB. Is Trauma-associated Sleep Disorder a subtype of RBD? International RBD Study Group Meeting, Copenhagen, 2019 [Oral presentation]
- Yao C, Wolfson C, Pelletier A, Postuma RB. Clinical Features of REM Sleep Behavior Disorder in the population-based Canadian Longitudinal Study on Aging Cohort: Can we improve the screening tools? CLSA Webinar Series 2018 [Oral presentation]
- Gosselin N. (2018) Obstructive sleep apnea and risk of cognitive decline, Sleep Grand Rounds, University of Calgary. October 2018 [Oral presentation]
- Yao C, Pelletier A, Postuma RB. Detecting Early Stage Parkinsonism in Possible REM Sleep Behavior Disorder. International RBD Study Group Meeting, Munich, 2018 [Oral presentation]
- Thompson C, Carrier J, Moullec G, Cross N, Dang-Vu T, Postuma R, Paquet J, Gosselin N. (2018). Risk factors for obstructive sleep apnea and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging. 24th Congress of the European Sleep Research Society, Basel, Switzerland, September 2018. [Oral presentation]
- Yao C, Fereshtehnejad SM, Keezer MR, Wolfson C, Pelletier A, Postuma RB. Prevalence and associated factors for rem sleep behavior disorder: a nation-wide population-based study of 30,097 Canadian adults. Sleep Congress, Prague, 2017 [Oral presentation]
- Legault J, Thompson C, Carrier J, Gosselin N. (2019) Association between risk of obstructive sleep apnea and cognitive decline in older adults, World Sleep Congress, 20-25 September 2019, Vancouver, Canada [Poster presentation]
- Sheida Zolfaghari, Chun Yao, Cynthia Thompson, Nadia Gosselin, Alex Desautels, Thien Thanh Dang-Vu, Ronald B. Postuma, Julie Carrier, “Effects of Menopause on Sleep Symptoms: Canadian Longitudinal Study on Aging”, World Sleep Congress, 20-25 September 2019, Vancouver, Canada. [Poster presentation]
- Yao C, Wolfson C, Pelletier A, Postuma RB. Characteristics and Neurodegeneration in PTSD associated sleep disorder: a nation-wide population-based study. World Sleep Congress, Vancouver, 2019 [Poster presentation]
- Sheida Zolfaghari, Kaberi Dasgupta, Ronald B. Postuma, “P 191: Restless Leg Syndrome and Cardiovascular and Cerebrovascular Diseases in the Canadian Longitudinal Study on Aging”, XXIV World Congress on Parkinson’s Disease and Related Disorders, 16–19 June 2019, Montreal, Canada [Poster presentation]
- Yao C, Pelletier A, Fereshtehnejad SM, Cross N, Dang-Vu T, Postuma RB. Insomnia subtypes and Manifestations of Prodromal Neurodegeneration: a Nation-wide Population-based Study in the Canadian Longitudinal Study on Aging. World Congress on Parkinson’s Disease and Related Disorders, Montréal, 2019 [Poster presentation]
- Cross N, Chouchou F, Gosselin N, Carrier J, Thompson C, Postuma R, Dang-Vu TT. Insomnia and cognitive function in older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging; presented at the 24th Congress of the European Sleep Research Society, Basel (Switzerland), Sept 2018. [Poster presentation]
Project 4
- Povitz M, Bansback N, Fenton M, Almeida F, Ratycz D, Huynh N, Ayas N, Pendharkar S. Workplace and driving consequences of sleepiness in Canadians with obstructive sleep apnea: results of a market research survey. World Sleep 2019 Meeting, September 2019.
- Fenton M, Ayas N, Povitz M, Bansback N, Almeida F, Huynh N, Ratycz D, Pendharkar SR. Does clinical care for OSA differ between Canadian jurisdictions with and without government funding for CPAP? Results of an online patient survey. World Sleep 2019 Meeting, September 2019.
- Bansback N. Improving shared decision making in sleep apnea management: technological tools and user preferences. World Sleep Conference symposium.
- Mona M Hamoda; Bernardo Peres; Yuuya Kohzuka; Waled M. Alshhrani; Najib T. Ayas; Nelly Hyunh; Fernanda R. Almeida. Positive Airway Pressure and Mandibular Advancement Splints; a Randomized Controlled Trial. International Academy of Dental Research, oral presentation, June 2019
- M.M.F. Hamoda, N. Bansback, N. Hyunh, F. Series, B.U. Peres, Y. Kohzuka, W. Alshhrani, N. Ayas, F.R. Almeida. Obstructive Sleep Apnea (OSA) Treatment Preference Using the Decision Aid Tool in Recently Diagnosed, Treatment-Naïve Patients. ATS 2018
- Trenaman L, F Almeida, L Lynd, S Pendharkar, N Ayas, N Bansback. Adherence to Treatment Is Associated with Initial Informed Treatment Preference in Patients with Obstructive Sleep Apnea. Society for Medical Decision Making. 2018.
- Pendharkar SR. The Use of Alternative Care Providers in the Management of Sleep-Disordered Breathing: Improving Access through Innovation. Alberta Respiratory Centre Research Seminar, University of Alberta
- Thornton CS, Santana MJ, Penz ED, Flemons WW, Tsai WH, Fraser KL, Hanly PJ, Pendharkar SR. The relationship between wait times and clinical outcomes for patients with severe sleep-disordered breathing. American Thoracic Society International Conference 2018.
- Pendharkar, SR. The Use of Alternative Care Providers in the Management of Sleep-Disordered Breathing across the Severity Spectrum. Canadian Sleep Society National Conference (April 29, 2017) (Symposium title: Emerging Innovations in Health Service Delivery for Sleep-Disordered Breathing).
- Ayas NT. Service Delivery Models for Sleep-Disordered Breathing: A Cross Canada Comparison Canadian Sleep Society National Conference (April 29, 2017) (Symposium title: Emerging Innovations in Health Service Delivery for Sleep-Disordered Breathing).
- N Bansback, L Trenaman, F Almeida, L Lynd, S Pendharkar, N Ayas. Adherence to treatment is associated with initial informed treatment preference in patients with obstructive sleep apnea. World sleep conference 2017. Sleep Medicine 40:e20-e21.